Fungal infection, when present , is invariably between the clefts or on the undersurface of the toes. This type of infection produces relatively slight discomfort , but its real importance lies in the fact that it paves the way for the entry of bacteria into the foot. More commonly, however, bacterial entry is via a traumatic lesion. The result of bacterial invasion into a foot already at risk by disease of both nerves and blood vessels, is usually severe.